Angela Zampella Selected Research

7-hydroxytheonellasterol

11/2012	Marine sponge steroids as nuclear receptor ligands.
1/2012	Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis.

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Angela Zampella Research Topics

Disease

12	Inflammation (Inflammations) 10/2022 - 07/2011
8	Fatty Liver 01/2022 - 01/2012
8	Cholestasis 01/2020 - 01/2012
6	Colitis 01/2022 - 07/2011
5	Non-alcoholic Fatty Liver Disease 01/2022 - 01/2018
5	Pruritus (Itching) 10/2021 - 01/2015
5	Neoplasms (Cancer) 01/2021 - 10/2005
4	Liver Diseases (Liver Disease) 10/2021 - 01/2012
4	Fibrosis (Cirrhosis) 06/2020 - 01/2015
4	Insulin Resistance 10/2019 - 05/2012
4	Obesity 01/2019 - 01/2013
3	Hepatitis 01/2020 - 01/2017
3	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018 - 01/2017
2	Stomach Neoplasms (Stomach Cancer) 01/2021 - 01/2016
2	Acute Liver Failure (Fulminant Hepatic Failure) 01/2020 - 04/2019
2	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2020 - 05/2012
2	Body Weight (Weight, Body) 10/2019 - 01/2013
2	Type 2 Diabetes Mellitus (MODY) 01/2019 - 01/2015
2	Dyslipidemias (Dyslipidemia) 02/2014 - 01/2012
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 11/2013 - 07/2011
1	COVID-19 10/2022
1	Crohn Disease (Crohn's Disease) 01/2022
1	Vascular System Injuries 01/2022
1	Lung Diseases (Lung Disease) 01/2020
1	Chemical and Drug Induced Liver Injury 01/2020
1	Disease Progression 01/2020
1	Asthma (Bronchial Asthma) 01/2020
1	Autoimmune Diseases (Autoimmune Disease) 01/2020
1	Dysbiosis 10/2019
1	Alcoholic Fatty Liver 01/2019
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019
1	Wasting Syndrome (Wasting Disease) 01/2017
1	Adenocarcinoma 01/2016
1	Portal Hypertension 01/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2014
1	Rheumatoid Arthritis 12/2013
1	Arthritis (Polyarthritis) 12/2013

Drug/Important Bio-Agent (IBA)

19	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 01/2012
15	LigandsIBA 10/2022 - 11/2011
6	CholesterolIBA 01/2022 - 05/2012
4	Messenger RNA (mRNA)IBA 01/2022 - 01/2016
4	LipidsIBA 01/2022 - 01/2013
4	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2018 - 11/2011
3	Proteins (Proteins, Gene)FDA Link 10/2022 - 01/2016
3	GTP-Binding Proteins (G-Protein)IBA 01/2022 - 01/2019
3	obeticholic acidIBA 01/2020 - 01/2018
3	isothiocyanic acidIBA 01/2020 - 01/2015
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2019 - 01/2015
3	CollagenIBA 01/2018 - 12/2013
3	6-ethyl-3,7-dihydroxycholan-24-olIBA 10/2017 - 01/2015
2	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 01/2022 - 01/2020
2	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2020 - 04/2019
2	FructoseIBA 10/2019 - 01/2017
2	BAR502IBA 01/2017 - 01/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2015 - 01/2013
2	CytokinesIBA 12/2013 - 07/2011
2	cholan-2,3,24-tryl-2,3,24-trisulfateIBA 12/2013 - 07/2011
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2013 - 01/2012
2	7-hydroxytheonellasterolIBA 11/2012 - 01/2012
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 10/2022
1	EnzymesIBA 10/2022
1	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2022
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022
1	Glucagon-Like Peptides (Enteroglucagon)IBA 01/2022
1	Atorvastatin (Lipitor)FDA Link 01/2022
1	oxidized low density lipoproteinIBA 10/2021
1	EstersIBA 01/2021
1	FlavonoidsIBA 01/2021
1	GlycosidesIBA 01/2021
1	pelargonidinIBA 01/2021
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2021
1	zafirlukast (Accolate)FDA LinkGeneric 01/2020
1	pranlukastIBA 01/2020
1	4-aminophenolIBA 01/2020
1	montelukast (Singulair)FDA Link 01/2020
1	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 10/2019
1	muricholic acidIBA 10/2019
1	Interleukin-6 (Interleukin 6)IBA 10/2019
1	compound 20IBA 04/2019
1	Galactosylceramides (Galactocerebrosides)IBA 01/2019
1	Concanavalin AIBA 01/2019
1	BilirubinIBA 01/2018
1	AlbuminsIBA 01/2018
1	OxazoloneIBA 01/2017
1	Triglycerides (Triacylglycerol)IBA 01/2017
1	Trinitrobenzenesulfonic AcidIBA 01/2017
1	Apolipoprotein C-II (ApoC2)IBA 01/2017
1	Cadherins (E-Cadherin)IBA 01/2016
1	Endothelin-1 (Endothelin 1)IBA 01/2015
1	Betulinic AcidIBA 01/2015
1	Alkaline PhosphataseIBA 01/2015
1	heteroneminIBA 01/2014
1	Terpenes (Terpenoids)IBA 01/2014
1	Chemokine CCL5IBA 12/2013
1	AntibodiesIBA 12/2013
1	Pregnane X ReceptorIBA 12/2013

Therapy/Procedure

7	Therapeutics 01/2021 - 01/2012
2	Ligation 01/2020 - 01/2012
2	Liver Transplantation 01/2020 - 04/2019
1	Intradermal Injections 01/2015